Claire's romantic interlude with the football quarterback takes a tragic turn. Hiro convinces his friend, Ando, that it is their destiny to travel to America to save the world. Meanwhile, Nathan uses Peter's accident for his own political gain. Officer Matt Parkman, Mohinder Suresh, and the FBI are all on the trail of the mysterious Sylar.
Los Angeles Police Officer Matt Parkman is working crowd control at a murder scene when he alone begins to hear the muffled cries of a little girl somewhere in the house. Claire's heroism brings her unwanted attention. Peter comes closer to learning the truth about his and Nathan's powers. Hiro finds a comic book which leads him to Isaac.
In New York, Peter Petrelli is the younger brother Nathan Petrelli, an overly ambitious and unscrupulous candidate for the next New York congressman, and he dreams and believes that he can fly. He decides to prove his theory and jumps from the roof of a building in an alley and his brother flies and saves him. In Texas, cheerleader Claire Bennet learns that she is literally indestructible and can not harm herself or die. She saves a fireman from a fire on a derailed train, but does not take the credit. In Tokyo, Hiro Nakamura believes he can control time and space continuum. In India, Mohinder Suresh moves to the Brooklyn, New York, where his father, that was researching a secret project called Genesis about genome and DNA, is killed in a taxi cab. But a mysterious man wearing horn-rimmed glasses, might pose a threat to him. In Lower Manhattan, the painter Isaac Mendez paints pictures of the future in which his girlfriend and drug sponsor, Simone, is skeptic to his claims to see in the future. In Las Vegas, stripper Niki Sanders borrows $30,000 from a powerful local mobster to get her young son, Micah, into school, and does not have the money to pay her loan. She sees a different image of her in the mirror, and when two gangsters come to her house to collect the money, one of them hits her and she faints. Later Nikki wakes up, and the two thugs are dead... literally torn apart by her evil alter ego Jessica. In Los Angeles, Matt Parkman is an overly ambitious beat policeman who discovers that he can 'read' peoples thoughts and is forced to help the FBI search for a wanted Saudi national, named Amid, who also discovers that he has the ability to create nuclear radiation in which his former AQ cell wants him to build a nuclear bomb for them. In Utah, Niki's husband and Micah's father, D.L. imprisoned for robbery charges, discovers that he can literally 'walk' through walls.